Chronic MA use has been linked to significant impairments in different arenas of neuropsychological function. To better understand this issue, a computerized literature search PubMed, was used to collect research studies examining the neurobiological and neuropsychiatric consequences of chronic MA use. View on PubMed. Save to Library Save. Create Alert Alert. Launch Research Feed Feed. Share This Paper. Background Citations. Methods Citations. Results Citations. Topics from this paper.
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MA intoxication has been associated with significant psychiatric and medical comorbidity. Research in animal models and human subjects reveals complicated mechanisms of neurotoxicity by which chronic MA use affects catecholamine neurotransmission. This pathology may underlie the characteristic cognitive deficits that plague chronic MA users, who experience impairments in memory and learning, psychomotor speed, and information processing. These impairments have the potential to compromise, in turn, the ability of MA abusers to engage in, and benefit from, psychosocially based chemical-dependency treatment.
Development of pharmacological interventions to improve these cognitive impairments in this population may significantly improve the degree to which they may be able to participate in treatment. Atypical antipsychotics may have some promise in this regard.
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|Professional dissertation methodology ghostwriter service for masters||Injury related to manufacture Manufacture of potent forms of methamphetamine involves relatively simple chemical processes [ 45253 ]. Significant testing bias may exist [ 30 ], and there may also be an underestimation of drug use as those who admit to using drugs are usually tested [ 31 ]. National Institute on Drug Abuse: Methamphetamine: abuse and addiction. Methamphetamine :. Availability of MA has markedly increased in the United States due to recent technological improvements in both mass production and clandestine synthesis, leading to significant public health, legal, and environmental problems. The childhood obesity research paper of this paper is to provide a critical review of the English language peer reviewed and 'grey' literature on the association between methamphetamine use and injury. These conditions are not conducive to safe driving [ 35 ], and may be a mechanism of crash causation [ 36 ].|
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|Cover letter physician assistant||View 1 excerpt, cites background. These behaviours may contribute to offenders being more likely to be pursued by police [ 18 ]. Methamphetamine abuse: epidemiologic issues and implications: Research Monograph, Family and relationship breakdown is typically associated with drug dependence, and any aggression and violence resulting as a consequence of methamphetamine-induced paranoia, hostility and application writing for job is particularly likely to be manifest in domestic violence [ 3 ]. New Zealand Herald. There is potential for cheap content editing services us contamination of emergency department ED personnel in cases where individuals contaminated by the processes of methamphetamine manufacture have presented at medical centres [ 5770 ].|
|Thesis on wind energy pdf||Methamphetamine is a powerful psychostimulant which has a high dependence liability [ 12 ] and can be readily manufactured from precursor substances which are common ingredients of 'over the counter' cold remedies [ 34 ]. Logan, Fligner and Haddix's review of Washington State deaths in which methamphetamine was detected in the blood of the deceased found the direct toxic effects of the drug caused or contributed to over a third of the deaths. Other reported effects of chronic use include insomnia, malnutrition, involuntary movements, increased psychomotor activity, elevated blood pressure and heart rate implications of chronic methamphetamine use a literature review resulting in myocardial infarction or stroke [ 9 — 12 ]. Further sources described cases and others described injury risk as part of an overall review of methamphetamine misuse. Evidence for long-term neurotoxicity associated with methamphetamine abuse.|
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In addition to being addicted to methamphetamine, people who use methamphetamine long term may exhibit symptoms that can include significant anxiety, confusion, insomnia, mood disturbances, and violent behavior. These and other problems reflect significant changes in the brain caused by misuse of methamphetamine. Neuroimaging studies have demonstrated alterations in the activity of the dopamine system that are associated with reduced motor speed and impaired verbal learning.
Research in primate models has found that methamphetamine alters brain structures involved in decision-making and impairs the ability to suppress habitual behaviors that have become useless or counterproductive. The two effects were correlated, suggesting that the structural change underlies the decline in mental flexibility.
Methamphetamine misuse also has been shown to have negative effects on non-neural brain cells called microglia. These cells support brain health by defending the brain against infectious agents and removing damaged neurons. Too much activity of the microglial cells, however, can assault healthy neurons. A study using brain imaging found more than double the levels of microglial cells in people who previously misused methamphetamine compared to people with no history of methamphetamine misuse, which could explain some of the neurotoxic effects of methamphetamine.
Some of the neurobiological effects of chronic methamphetamine misuse appear to be, at least, partially reversible. Function in other brain regions did not recover even after 14 months of abstinence, indicating that some methamphetamine-induced changes are very long lasting.
In addition to the neurological and behavioral consequences of methamphetamine misuse, long-term users also suffer physical effects, including weight loss, severe tooth decay and tooth loss "meth mouth" , and skin sores. Skin sores are the result of picking and scratching the skin to get rid of insects imagined to be crawling under it.
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