implications of chronic methamphetamine use a literature review

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Implications of chronic methamphetamine use a literature review

Chronic MA use has been linked to significant impairments in different arenas of neuropsychological function. To better understand this issue, a computerized literature search PubMed, was used to collect research studies examining the neurobiological and neuropsychiatric consequences of chronic MA use. View on PubMed. Save to Library Save. Create Alert Alert. Launch Research Feed Feed. Share This Paper. Background Citations. Methods Citations. Results Citations. Topics from this paper.

Drug abuse Pharmacology Synaptic Transmission emotional dependency. Paper Mentions. Blog Post. Methamphetamine Intoxication. News Article. The Chemistry of Breaking Bad. Citation Type. Has PDF. Publication Type. More Filters. Highly Influenced. View 13 excerpts, cites background. Research Feed. View 3 excerpts, cites background.

MA intoxication has been associated with significant psychiatric and medical comorbidity. Research in animal models and human subjects reveals complicated mechanisms of neurotoxicity by which chronic MA use affects catecholamine neurotransmission. This pathology may underlie the characteristic cognitive deficits that plague chronic MA users, who experience impairments in memory and learning, psychomotor speed, and information processing. These impairments have the potential to compromise, in turn, the ability of MA abusers to engage in, and benefit from, psychosocially based chemical-dependency treatment.

Development of pharmacological interventions to improve these cognitive impairments in this population may significantly improve the degree to which they may be able to participate in treatment. Atypical antipsychotics may have some promise in this regard.

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Professional dissertation methodology ghostwriter service for masters Injury related to manufacture Manufacture of potent forms of methamphetamine involves relatively simple chemical processes [ 45253 ]. Significant testing bias may exist [ 30 ], and there may also be an underestimation of drug use as those who admit to using drugs are usually tested [ 31 ]. National Institute on Drug Abuse: Methamphetamine: abuse and addiction. Methamphetamine :. Availability of MA has markedly increased in the United States due to recent technological improvements in both mass production and clandestine synthesis, leading to significant public health, legal, and environmental problems. The childhood obesity research paper of this paper is to provide a critical review of the English language peer reviewed and 'grey' literature on the association between methamphetamine use and injury. These conditions are not conducive to safe driving [ 35 ], and may be a mechanism of crash causation [ 36 ].
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Cover letter physician assistant View 1 excerpt, cites background. These behaviours may contribute to offenders being more likely to be pursued by police [ 18 ]. Methamphetamine abuse: epidemiologic issues and implications: Research Monograph, Family and relationship breakdown is typically associated with drug dependence, and any aggression and violence resulting as a consequence of methamphetamine-induced paranoia, hostility and application writing for job is particularly likely to be manifest in domestic violence [ 3 ]. New Zealand Herald. There is potential for cheap content editing services us contamination of emergency department ED personnel in cases where individuals contaminated by the processes of methamphetamine manufacture have presented at medical centres [ 5770 ].
Thesis on wind energy pdf Methamphetamine is a powerful psychostimulant which has a high dependence liability [ 12 ] and can be readily manufactured from precursor substances which are common ingredients of 'over the counter' cold remedies [ 34 ]. Logan, Fligner and Haddix's review of Washington State deaths in which methamphetamine was detected in the blood of the deceased found the direct toxic effects of the drug caused or contributed to over a third of the deaths. Other reported effects of chronic use include insomnia, malnutrition, involuntary movements, increased psychomotor activity, elevated blood pressure and heart rate implications of chronic methamphetamine use a literature review resulting in myocardial infarction or stroke [ 9 — 12 ]. Further sources described cases and others described injury risk as part of an overall review of methamphetamine misuse. Evidence for long-term neurotoxicity associated with methamphetamine abuse.
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In addition to being addicted to methamphetamine, people who use methamphetamine long term may exhibit symptoms that can include significant anxiety, confusion, insomnia, mood disturbances, and violent behavior. These and other problems reflect significant changes in the brain caused by misuse of methamphetamine. Neuroimaging studies have demonstrated alterations in the activity of the dopamine system that are associated with reduced motor speed and impaired verbal learning.

Research in primate models has found that methamphetamine alters brain structures involved in decision-making and impairs the ability to suppress habitual behaviors that have become useless or counterproductive. The two effects were correlated, suggesting that the structural change underlies the decline in mental flexibility.

Methamphetamine misuse also has been shown to have negative effects on non-neural brain cells called microglia. These cells support brain health by defending the brain against infectious agents and removing damaged neurons. Too much activity of the microglial cells, however, can assault healthy neurons. A study using brain imaging found more than double the levels of microglial cells in people who previously misused methamphetamine compared to people with no history of methamphetamine misuse, which could explain some of the neurotoxic effects of methamphetamine.

Some of the neurobiological effects of chronic methamphetamine misuse appear to be, at least, partially reversible. Function in other brain regions did not recover even after 14 months of abstinence, indicating that some methamphetamine-induced changes are very long lasting.

In addition to the neurological and behavioral consequences of methamphetamine misuse, long-term users also suffer physical effects, including weight loss, severe tooth decay and tooth loss "meth mouth" , and skin sores. Skin sores are the result of picking and scratching the skin to get rid of insects imagined to be crawling under it.

National Institutes of Health. Colby, J. Psychiatry Research: Neuroimaging, 2 , Derauf, C. Prenatal methamphetamine exposure and inhibitory control among young school-age children. Journal of Pediatrics, 3 , — Diaz, S. Effects of prenatal methamphetamine exposure on behavioral and cognitive findings at 7. The Journal of Pediatrics. Himes, S. Risk of neurobehavioral disinhibition in prenatal methamphetamine- exposed young children with positive hair toxicology results.

Therapeutic drug monitoring. Kiblawi, Z. Journal of developmental and behavioral pediatrics: JDBP, 34 1 , Kirlic, N. Cortisol reactivity in two-year-old children prenatally exposed to methamphetamine. Journal of studies on alcohol and drugs, 74 3 , LaGasse, L.

Prenatal methamphetamine exposure and childhood behavior problems at 3 and 5 years of age. Pediatrics, 4 , Neurotoxicology and teratology, 33 1 , Lindsay, B. Against professional advice: Treatment attrition among pregnant methamphetamine users. Substance abuse and rehabilitation, 2, Lu, L. Effects of prenatal methamphetamine exposure on verbal memory revealed with fMRI.

Journal of developmental and behavioral pediatrics: JDBP, 30 3 , Moore, D. In Preece, P. Roos, A. Structural brain changes in prenatal methamphetamine-exposed children. Metabolic brain disease, Roussotte, F. Frontostriatal connectivity in children during working memory and the effects of prenatal methamphetamine, alcohol, and polydrug exposure. Developmental neuroscience, 34 1 , Siegel, J.

Methamphetamine exposure during brain development alters the brain acetylcholine system in adolescent mice. Journal of neurochemistry, 1 , Thompson, B. Prenatal exposure to drugs: effects on brain development and implications for policy and education. Nature Reviews Neuroscience, 10 4 , Asanbe, C. Mental health disorders in children of non-drug- abusing parents A sample from a rural community devastated by methamphetamine.

Journal of Child Health Care, 16 1 , Brensilver, M. Drug and alcohol review, 32 5 , Carlson, B. Methamphetamine-involved parents in the child welfare system: Are they more challenging than other substance-involved parents?. Journal of Public Child Welfare, 6 3 , Caroner-Lopez, K. Journal of Drug Issues, 42 3 , — Carroll Chapman, S. Substance use among adolescent mothers: A review.

Children and youth services review, 35 5 , Castaneto, M. Identifying methamphetamine exposure in children. Therapeutic drug monitoring, 35 6 , Chomchai, C. Stimulant methamphetamine and dextromethorphan use among Thai adolescents: implications for health of women and children. Journal of Medical Toxicology, 8 3 , Grant, P. Evidence of methamphetamine exposure in children removed from clandestine methamphetamine laboratories. Pediatric emergency care, 26 1 , Haight, W.

Children and youth services review, 32 10 , Hawkrigg, S. Children and clandestine drug laboratories: The unseen victims. The Medical journal of Australia, 11 , Liles, B. Perceived child behavior problems, parenting stress, and maternal depressive symptoms among prenatal methamphetamine users. Marshall, B. Health outcomes associated with methamphetamine use among young people: a systematic review.

Addiction, 6 , Messina, N. Children exposed to methamphetamine use and manufacture. Parental methamphetamine use and manufacture: child and familial outcomes. Journal of public child welfare, 6 3 , Pennar, A. Drug endangered children: Examining children removed from methamphetamine laboratories.

Children and Youth Services Review, 34, — Piper, B. Pharmacology Biochemistry and Behavior, 98 3 , Semple, S. Methamphetamine-using parents: the relationship between parental role strain and depressive symptoms. Journal of studies on alcohol and drugs, 72 6 , Retrieved from. Sheridan, K. The role of grandparents in preventing aggressive and other externalizing behavior problems in children from rural, methamphetamine-involved families.

Children and youth services review, 33 9 , Smith, L. Maternal depression and prenatal exposure to methamphetamine: neurodevelopmental findings from the infant development, environment, and lifestyle ideal study. Depression and anxiety, 29 6 , Twomey, J.

Prenatal methamphetamine exposure, home environment, and primary caregiver risk factors predict child behavioral problems at 5 years. American Journal of Orthopsychiatry, 83 1 , VanderWaal, C. Smurfing in small toxic meth labs: Impact of state methamphetamine precursor policies. Journal of Policy Practice, 12 3 , Zapata, L.

Methamphetamine use is independently associated with recent risky sexual behaviors and adolescent pregnancy. Journal of School Health, 78 12 , Armstrong, T. A multivariate analysis of the sociodemographic predictors of methamphetamine production and use. Bairan, A. Methamphetamine use among suburban women: Implications for nurse practitioners. Journal of the American Association of Nurse Practitioners. Bowen, A. An investigation of bioecological influences associated with first use of methamphetamine in a rural state.

Ciketic, S. A review of psychological and pharmacological treatment options for methamphetamine dependence. Journal of Substance Use, 17 4 , Coffin, P. Addiction, 4 , Evans, L. High in the heartland: A look at the regional factors that contribute to methamphetamine addiction in the great plains. In Nelson, A. Ghasemi, A. Effect of empowerment based intervention program on promoting lifestyle among methamphetamine addict and their families compare with non-addicts.

World Applied Sciences Journal, 22 2. Gruenewald, P.

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